From Early Discovery to Late-Phase Studies: Advancing Oncology with HAP Technology

High-Affinity Probes (HAPs) are engineered molecular

tools designed for in situ detection and quantification of

therapeutic binding sites on patient tumor tissue. They

enable precise assessment of target accessibility,

binding site density, and spatial distribution, providing

critical insights for biomarker validation, patient

stratification, and therapy optimization. HAPs are

compatible with a wide range of therapeutics, including

small molecules, monoclonal antibodies, bispecific

antibodies, ADCs, radioligands, and CAR-T cell targets,

making them versatile solutions for advancing precision

oncology.


 

Specific Examples of HAP Products by Stage

High-Affinity Probes (HAPs) offer a wide range of applications across the drug development lifecycle. Here are just a few examples of how HAP-based products can support different stages:


  • Preclinical Development: HAP-Based Preclinical Tumor Profiling - Validate therapeutic target accessibility and

    binding site density in preclinical models or primary tumor samples to guide your clinical trial design.

  • Clinical Trials: HAP-Based Clinical Trial Stratification - Stratify patients based on the presence and accessibility

    of drug targets in tumor tissues to enrich trial populations pro- or retrospectively.

  • Post-Marketing: HAP-Based Personalized Therapy Identification – Use HAPs to assess drug-target interactions in tumor samples from patients with recurrent or refractory disease, providing  tailored treatment recommendations and exploring new therapeutic opportunities.

Partner with Us to Advance Precision Oncology

We invite you to connect with us to explore how our High-Affinity Probe (HAP) technology can address your research and clinical objectives. Whether your focus is on custom probe development, enhancing clinical trial strategies, or advancing therapeutic profiling, our team is ready to provide tailored support and expert guidance.


Contact us to discuss your specific needs, request detailed information, or learn more about how HAP technology can contribute to your success in drug development and precision oncology.

Bavarian Biotech GmbH 

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